Houston Astros at San Diego Padres Betting Pick – Sep 16, 2024

The Astros and Padres are set to face off in an interleague matchup at 9:40 PM ET on Monday. This one is being played at PETCO Park in San Diego, and the Astros are 4-0 in their last four games, while the Padres have won three straight and are 85-65 overall. Houston leads the AL West, while the Padres are second in the NL West.
Yu Darvish will be on the mound for the Padres, and they are the betting favorite at -139 over the Astros and Spencer Arrighetti (+118). The over/under line is sitting at 8 runs.
Astros Aim for Fifth Straight Win on the Road Against Padres
The Astros are 81-68 and have won four straight games, and they are 25-20 in divisional games. They are four games ahead of the Mariners in the AL West. Today, they are on the road to face the Padres. The Astros have a 42-32 record at home and are 39-36 on the road. As the road underdog, they are 15-14. Their over/under record is 61-83, and the line for today’s game is set at 8 runs.
Spencer Arrighetti is 7-12 this season with a 4.72 ERA and a 1.42 WHIP. He has won two straight starts and has a run line record of 42-33. The Astros are 6th in runs per game at home, averaging 4.9 runs, and they have a .262 batting average, which is 3rd in the league. Yordan Alvarez leads the team in batting average at .308 and has 34 home runs and 84 RBI. He’s hitting .297 with 4 home runs in his last 9 games. The Astros have a few players on hitting streaks, including Jon Singleton, Jason Heyward, Victor Caratini, and Jeremy Peña, who all have 3-game hitting streaks.
Padres Look to Extend Winning Streak as Darvish Takes the Mound Against Astros
San Diego is 3.5 games behind the Dodgers in the NL West and will host the Astros today. The Padres are 85-65 overall and have won three straight games. They are 24-22 in divisional games this year. The Padres are 55-41 when favored and 30-24 as the underdog. Their overall series record is 29-15-6. San Diego is 40-35 at home and 45-30 on the road.
Yu Darvish will get the start for the Padres today and is 5-3 with a 3.52 ERA this season. He has three quality starts this year and is averaging 8.72 strikeouts per nine innings. The Padres are 47-28 on the run line on the road and 29-46 at home. The Padres have the best batting average in the MLB at .265 and are 4th in runs per game on the road at 5.1. The over/under line for today’s game is set at 8 runs, and the Padres are 80-67 to the over this season.
Padres Predicted to Edge Astros 6-5: Darvish Outduels Arrighetti in Tight Matchup
Our prediction for this Padres vs. Astros matchup is that the Padres will pick up a 6-5 win at home. Given that they are at -139 on the money line, that’s the route we recommend going for this one.
Looking at the starting pitchers, we have Yu Darvish finishing with six strikeouts, which is better than Spencer Arrighetti’s projection of six. However, we do have Darvish finishing with a higher ERA than Arrighetti.
Offensively, the Astros are projected to finish with nine hits compared to the Padres, who we have finishing with nine. The Astros are projected to hit more home runs, but the Padres are projected to strike out fewer times.