Kansas City Chiefs vs San Francisco 49ers Prediction – Week 7 NFL

Week 7 of the 2024 NFL season brings a highly anticipated rematch between the Kansas City Chiefs and the San Francisco 49ers, revisiting the Super Bowl 58 showdown. This time, the Chiefs enter the matchup as underdogs for the first time this season despite holding a perfect 5-0 record. Meanwhile, the 49ers are fresh off a much-needed win over the Seattle Seahawks in Week 6, bringing them back to .500 and the top of the NFC West.
Both teams have plenty to prove as they face off in a game that could have playoff implications down the line. Let’s dive into the odds, key players, and provide a prediction for this exciting matchup.
Chiefs Look to Maintain Unbeaten Streak
The Kansas City Chiefs have started the season strong, going 5-0, but they find themselves as underdogs for the first time this year. Quarterback Patrick Mahomes has been efficient but not as dominant as in past seasons, with six touchdowns and six interceptions so far. Without key offensive weapons Rashee Rice and Isiah Pacheco, Mahomes will need to rely heavily on veteran tight end Travis Kelce, who remains the focal point of Kansas City’s passing attack.
The Chiefs’ defense has been stellar against the run, and that could be crucial as they aim to slow down a 49ers offense that leans heavily on its ground game. Kansas City has thrived under head coach Andy Reid coming off a bye week, and they’ll look to continue that trend.
49ers Face Injuries in Key Positions
The San Francisco 49ers, at 3-3, have struggled with injuries, particularly on offense. Star running back Christian McCaffrey is out, and several other players, including Jordan Mason, are questionable. This puts added pressure on wide receiver Deebo Samuel, who delivered a 100-yard performance in Week 6. Samuel will need to take on an expanded role in both the running and passing games to give San Francisco a fighting chance.
Quarterback Brock Purdy has been efficient, but facing the Chiefs’ defense will be one of his toughest tests yet. The 49ers’ ability to balance the run and pass will be key, but they’ll need to protect the football and avoid mistakes against Kansas City’s opportunistic defense.
Prediction: Chiefs Continue to Roll
This matchup is expected to be a hard-fought contest, but Kansas City’s offense, led by Mahomes and Kelce, may prove too much for the 49ers to handle, especially with San Francisco dealing with significant injuries. Mahomes has a track record of excelling as an underdog, and Andy Reid’s success after a bye week is hard to bet against.
Look for the Chiefs to cover the spread and win outright on the moneyline, with the under 47.5 being a strong play due to both teams’ strong defensive units.