Sports Betting Picks

St. Louis Cardinals vs Pittsburgh Pirates – MLB Preview – Sep 22, 2026

The St. Louis Cardinals will visit the Pittsburgh Pirates at PNC Park on Tuesday, September 22, 2026. This MLB regular season game starts at 6:40 PM and will be aired on SN PT. The weather forecast predicts a mild day with a light breeze and light rain.

The Cardinals have a record of 76-80 and are fourth in the NL Central. Their current streak is one win, but they have gone 4-6 in their last ten games. The Pirates are third in the NL Central with a 79-77 record and have won their last four games. They have a 6-4 record in their last ten games.

St. Louis Cardinals Team Preview

The St. Louis Cardinals are set to play against the Pittsburgh Pirates. In their recent games, the Cardinals have struggled, losing four out of their last five. However, they secured a win on September 20th, with key contributions from Iván Herrera and Leo Bernal, who each hit home runs.

Iván Herrera has been a standout player for the Cardinals. In the last game, he went 2 for 4 with two home runs, driving in two runs. Alec Burleson also remains a key player, leading the team in home runs and RBIs this season.

Starting pitcher Andre Pallante will take the mound for the Cardinals. His season record is 12-7 with a 3.70 ERA. The Cardinals will rely on Pallante’s performance to give them a chance to win against the Pirates.

Pittsburgh Pirates Team Preview

The Pittsburgh Pirates have been strong at home recently. They won their last four games at home, with the most recent being a 4-3 victory over the Kansas City Royals. In that game, Rafael Flores Jr. had a big impact with a home run and two RBIs.

Brandon Lowe has been a key player for the Pirates. He leads the team with 33 home runs and 93 RBIs. Nick Gonzales has also contributed with a .302 batting average, which is the best on the team.

The Pirates’ starting pitcher for the next game is Jared Jones. This season, he has a 4.17 ERA and 109 strikeouts. The Pirates hope his performance helps them continue their winning streak at home.

Betting Prediction

The Pirates have a strong pitching staff, with a team ERA of 4.19, which ranks 19th. They also rank 9th in batting average against at .238. This shows they have the ability to limit opposing teams from scoring many runs.

The Cardinals’ offense is ranked in the middle of the pack. Their batting average is .242, which is 13th in the league. With these numbers, they may struggle to score heavily against the Pirates.

Both teams have a solid record of keeping games close. The Cardinals’ runline is +1.5, indicating that oddsmakers expect a competitive game. Additionally, the Pirates have given up the fewest home runs this season, which further supports a lower total score.

  • Pick: Total Under 7.5 (-125)

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